BOS complex subunit TMEM147 (TMEM147)
Homo sapiens — UniProt Q9BVK8
Data last refreshed: (UniProt release unknown)
Key facts
BOS complex subunit TMEM147 (TMEM147) is a protein from Homo sapiens identified by UniProt accession Q9BVK8, 224 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q9BVK8; gene symbol TMEM147.
- Organism: Homo sapiens.
- Length: 224 amino acids.
- Top disease associations (Open Targets): neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-pelger-huet anomaly, Poor speech and Abnormal facial shape.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BOS complex subunit TMEM147 |
|---|---|
| UniProt accession | Q9BVK8 |
| Gene | TMEM147 |
| Organism | Homo sapiens |
| Length | 224 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-pelger-huet anomaly · score 0.68
- Poor speech · score 0.34
- Abnormal facial shape · score 0.34
- Intellectual disability, severe · score 0.34
- Motor delay · score 0.34
- Absent speech · score 0.34
- serum alanine aminotransferase measurement · score 0.23
- genetic disorder · score 0.19
- serum albumin measurement · score 0.17
- calcium measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BVK8-F1 | alphafold | PREDICTED | 92.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BVK8.
Amino-acid sequence (224 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM147?
The strongest Open Targets associations for TMEM147 are neurodevelopmental disorder with facial dysmorphism, absent language, and pseudo-pelger-huet anomaly, Poor speech, Abnormal facial shape, Intellectual disability, severe and Motor delay.
How long is the TMEM147 protein?
The Homo sapiens TMEM147 protein (UniProt Q9BVK8) is 224 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BVK8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BVK8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.