Nucleoporin p58/p45 (NUP58)
Homo sapiens — UniProt Q9BVL2
Data last refreshed: (UniProt release unknown)
Key facts
Nucleoporin p58/p45 (NUP58) is a protein from Homo sapiens identified by UniProt accession Q9BVL2, 599 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q9BVL2; gene symbol NUP58.
- Organism: Homo sapiens.
- Length: 599 amino acids.
- Top disease associations (Open Targets): influenza, HIV infection and viral disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nucleoporin p58/p45 |
|---|---|
| UniProt accession | Q9BVL2 |
| Gene | NUP58 |
| Organism | Homo sapiens |
| Length | 599 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- influenza · score 0.54
- HIV infection · score 0.54
- viral disease · score 0.53
- COVID-19 · score 0.37
- Histiocytosis · score 0.37
- clear cell renal carcinoma · score 0.28
- breast adenocarcinoma · score 0.25
- endometrial cancer · score 0.23
- cyst · score 0.03
- bacteriemia · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BVL2-F1 | alphafold | PREDICTED | 55.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BVL2.
Amino-acid sequence (599 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NUP58?
The strongest Open Targets associations for NUP58 are influenza, HIV infection, viral disease, COVID-19 and Histiocytosis.
How long is the NUP58 protein?
The Homo sapiens NUP58 protein (UniProt Q9BVL2) is 599 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BVL2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BVL2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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