Splicing factor 3B subunit 5 (SF3B5)
Homo sapiens — UniProt Q9BWJ5
Data last refreshed: (UniProt release unknown)
Key facts
Splicing factor 3B subunit 5 (SF3B5) is a protein from Homo sapiens identified by UniProt accession Q9BWJ5, 86 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q9BWJ5; gene symbol SF3B5.
- Organism: Homo sapiens.
- Length: 86 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neutrophil count and eosinophil percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Splicing factor 3B subunit 5 |
|---|---|
| UniProt accession | Q9BWJ5 |
| Gene | SF3B5 |
| Organism | Homo sapiens |
| Length | 86 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- neutrophil count · score 0.24
- eosinophil percentage of leukocytes · score 0.20
- resistin measurement · score 0.18
- sum of basophil and neutrophil counts · score 0.17
- eosinophil count · score 0.08
- myeloid white cell count · score 0.03
- lymphocyte percentage of leukocytes · score 0.02
- monocyte count · score 0.02
- systemic juvenile idiopathic arthritis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BWJ5-F1 | alphafold | PREDICTED | 91.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BWJ5.
Amino-acid sequence (86 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SF3B5?
The strongest Open Targets associations for SF3B5 are neurodegenerative disease, neutrophil count, eosinophil percentage of leukocytes, resistin measurement and sum of basophil and neutrophil counts.
How long is the SF3B5 protein?
The Homo sapiens SF3B5 protein (UniProt Q9BWJ5) is 86 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BWJ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BWJ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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