Splicing factor 3B subunit 5 (SF3B5)

About Splicing factor 3B subunit 5

Splicing factor 3B subunit 5 (SF3B5) is a protein from Homo sapiens identified by UniProt accession Q9BWJ5, 86 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Splicing factor 3B subunit 5
UniProt accession	Q9BWJ5
Gene	SF3B5
Organism	Homo sapiens
Length	86 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.33
neutrophil count · score 0.24
eosinophil percentage of leukocytes · score 0.20
resistin measurement · score 0.18
sum of basophil and neutrophil counts · score 0.17
eosinophil count · score 0.08
myeloid white cell count · score 0.03
lymphocyte percentage of leukocytes · score 0.02
monocyte count · score 0.02
systemic juvenile idiopathic arthritis · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BWJ5-F1	alphafold	PREDICTED	91.63	—

Amino-acid sequence (86 residues)

MTDRYTIHSQ LEHLQSKYIG TGHADTTKWE WLVNQHRDSY CSYMGHFDLL NYFAIAENES KARVRFNLME KMLQPCGPPA DKPEEN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards