E3 ubiquitin-protein ligase PHF7 (PHF7)
Homo sapiens — UniProt Q9BWX1
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase PHF7 (PHF7) is a protein from Homo sapiens identified by UniProt accession Q9BWX1, 381 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.
- UniProt accession: Q9BWX1; gene symbol PHF7.
- Organism: Homo sapiens.
- Length: 381 amino acids.
- Top disease associations (Open Targets): Progressive sensorineural hearing impairment, triglyceride measurement and azoospermia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase PHF7 |
|---|---|
| UniProt accession | Q9BWX1 |
| Gene | PHF7 |
| Organism | Homo sapiens |
| Length | 381 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (97)
Diseases linked to this target (Open Targets).
- Progressive sensorineural hearing impairment · score 0.11
- triglyceride measurement · score 0.09
- azoospermia · score 0.09
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- Female infertility due to fertilization defect · score 0.07
- spermatogenic failure 55 · score 0.07
- spermatogenic failure 3 · score 0.07
- spermatogenic failure 31 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BWX1-F1 | alphafold | PREDICTED | 76.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BWX1.
Amino-acid sequence (381 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PHF7?
The strongest Open Targets associations for PHF7 are Progressive sensorineural hearing impairment, triglyceride measurement, azoospermia, Male infertility with spermatogenesis disorder due to single gene mutation and partial chromosome Y deletion.
How long is the PHF7 protein?
The Homo sapiens PHF7 protein (UniProt Q9BWX1) is 381 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BWX1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BWX1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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