Glutathione hydrolase light chain 1 (GGTLC1)
Homo sapiens — UniProt Q9BX51
Data last refreshed: (UniProt release unknown)
Key facts
Glutathione hydrolase light chain 1 (GGTLC1) is a protein from Homo sapiens identified by UniProt accession Q9BX51, 225 residues long. MolForge cross-references it against 0 known binders and 545 disease associations.
- UniProt accession: Q9BX51; gene symbol GGTLC1.
- Organism: Homo sapiens.
- Length: 225 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, ulcerative colitis and cystatin C measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Glutathione hydrolase light chain 1 |
|---|---|
| UniProt accession | Q9BX51 |
| Gene | GGTLC1 |
| Organism | Homo sapiens |
| Length | 225 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (545)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- ulcerative colitis · score 0.30
- cystatin C measurement · score 0.10
- 46,XX gonadal dysgenesis · score 0.05
- multiple epiphyseal dysplasia, with severe proximal femoral dysplasia · score 0.05
- hypogonadotropic hypogonadism · score 0.05
- Kallmann syndrome · score 0.05
- multiple epiphyseal dysplasia · score 0.05
- multiple epiphyseal dysplasia type 4 · score 0.05
- Isolated follicle stimulating hormone deficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BX51-F1 | alphafold | PREDICTED | 93.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BX51.
Amino-acid sequence (225 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GGTLC1?
The strongest Open Targets associations for GGTLC1 are neurodegenerative disease, ulcerative colitis, cystatin C measurement, 46,XX gonadal dysgenesis and multiple epiphyseal dysplasia, with severe proximal femoral dysplasia.
How long is the GGTLC1 protein?
The Homo sapiens GGTLC1 protein (UniProt Q9BX51) is 225 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BX51 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BX51 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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