Sorbin and SH3 domain-containing protein 1 (SORBS1)
Homo sapiens — UniProt Q9BX66
Data last refreshed: (UniProt release unknown)
Key facts
Sorbin and SH3 domain-containing protein 1 (SORBS1) is a protein from Homo sapiens identified by UniProt accession Q9BX66, 1292 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.
- UniProt accession: Q9BX66; gene symbol SORBS1.
- Organism: Homo sapiens.
- Length: 1292 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, hematocrit and hemoglobin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sorbin and SH3 domain-containing protein 1 |
|---|---|
| UniProt accession | Q9BX66 |
| Gene | SORBS1 |
| Organism | Homo sapiens |
| Length | 1292 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (112)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- hematocrit · score 0.42
- hemoglobin measurement · score 0.40
- erythrocyte count · score 0.37
- body mass index · score 0.34
- PHF-tau measurement · score 0.32
- serum gamma-glutamyl transferase measurement · score 0.31
- cystatin C measurement · score 0.31
- creatinine measurement · score 0.30
- systolic blood pressure · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BX66-F1 | alphafold | PREDICTED | 46.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BX66.
Amino-acid sequence (1292 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SORBS1?
The strongest Open Targets associations for SORBS1 are neurodegenerative disease, hematocrit, hemoglobin measurement, erythrocyte count and body mass index.
How long is the SORBS1 protein?
The Homo sapiens SORBS1 protein (UniProt Q9BX66) is 1292 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BX66 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BX66 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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