Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4)
Homo sapiens — UniProt Q9BXB1
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) is a protein from Homo sapiens identified by UniProt accession Q9BXB1, 951 residues long. MolForge cross-references it against 0 known binders and 731 disease associations.
- UniProt accession: Q9BXB1; gene symbol LGR4.
- Organism: Homo sapiens.
- Length: 951 amino acids.
- Top disease associations (Open Targets): delayed puberty, self-limited, lean body mass and hair shape measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat-containing G-protein coupled receptor 4 |
|---|---|
| UniProt accession | Q9BXB1 |
| Gene | LGR4 |
| Organism | Homo sapiens |
| Length | 951 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (731)
Diseases linked to this target (Open Targets).
- delayed puberty, self-limited · score 0.58
- lean body mass · score 0.47
- hair shape measurement · score 0.47
- heel bone mineral density · score 0.46
- balding measurement · score 0.40
- cortical thickness · score 0.38
- osteoporosis · score 0.37
- postmenopausal osteoporosis · score 0.37
- diastolic blood pressure · score 0.37
- fat body mass · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BXB1-F1 | alphafold | PREDICTED | 78.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BXB1.
Amino-acid sequence (951 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LGR4?
The strongest Open Targets associations for LGR4 are delayed puberty, self-limited, lean body mass, hair shape measurement, heel bone mineral density and balding measurement.
How long is the LGR4 protein?
The Homo sapiens LGR4 protein (UniProt Q9BXB1) is 951 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BXB1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BXB1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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