N-acetylneuraminate lyase (NPL)
Homo sapiens — UniProt Q9BXD5
Data last refreshed: (UniProt release unknown)
Key facts
N-acetylneuraminate lyase (NPL) is a protein from Homo sapiens identified by UniProt accession Q9BXD5, 320 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.
- UniProt accession: Q9BXD5; gene symbol NPL.
- Organism: Homo sapiens.
- Length: 320 amino acids.
- Top disease associations (Open Targets): serum metabolite measurement, N-acetylneuraminate measurement and hypertriglyceridemia 2.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | N-acetylneuraminate lyase |
|---|---|
| UniProt accession | Q9BXD5 |
| Gene | NPL |
| Organism | Homo sapiens |
| Length | 320 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (143)
Diseases linked to this target (Open Targets).
- serum metabolite measurement · score 0.25
- N-acetylneuraminate measurement · score 0.13
- hypertriglyceridemia 2 · score 0.06
- cholesterol-ester transfer protein deficiency · score 0.06
- autosomal dominant mitochondrial myopathy with exercise intolerance · score 0.05
- myofibrillar myopathy 3 · score 0.05
- carnitine palmitoyl transferase II deficiency, myopathic form · score 0.05
- Combined hyperlipidemia · score 0.05
- thyroid hormone metabolism, abnormal, 2 · score 0.04
- GNE myopathy · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BXD5-F1 | alphafold | PREDICTED | 93.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BXD5.
Amino-acid sequence (320 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NPL?
The strongest Open Targets associations for NPL are serum metabolite measurement, N-acetylneuraminate measurement, hypertriglyceridemia 2, cholesterol-ester transfer protein deficiency and autosomal dominant mitochondrial myopathy with exercise intolerance.
How long is the NPL protein?
The Homo sapiens NPL protein (UniProt Q9BXD5) is 320 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BXD5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BXD5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.