Protein amnionless (AMN)
Homo sapiens — UniProt Q9BXJ7
Data last refreshed: (UniProt release unknown)
Key facts
Protein amnionless (AMN) is a protein from Homo sapiens identified by UniProt accession Q9BXJ7, 453 residues long. MolForge cross-references it against 1 known binders and 103 disease associations.
- UniProt accession: Q9BXJ7; gene symbol AMN.
- Organism: Homo sapiens.
- Length: 453 amino acids.
- Top disease associations (Open Targets): Gräsbeck-Imerslund disease, Imerslund-Grasbeck syndrome type 2 and Imerslund-Grasbeck syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein amnionless |
|---|---|
| UniProt accession | Q9BXJ7 |
| Gene | AMN |
| Organism | Homo sapiens |
| Length | 453 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (103)
Diseases linked to this target (Open Targets).
- Gräsbeck-Imerslund disease · score 0.74
- Imerslund-Grasbeck syndrome type 2 · score 0.73
- Imerslund-Grasbeck syndrome · score 0.65
- neurodegenerative disease · score 0.44
- megaloblastic anemia · score 0.37
- Decreased circulating vitamin B12 concentration · score 0.37
- serum gamma-glutamyl transferase measurement · score 0.32
- head and neck squamous cell carcinoma · score 0.26
- lung adenocarcinoma · score 0.23
- squamous cell lung carcinoma · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BXJ7-F1 | alphafold | PREDICTED | 80.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BXJ7.
Amino-acid sequence (453 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AMN?
The strongest Open Targets associations for AMN are Gräsbeck-Imerslund disease, Imerslund-Grasbeck syndrome type 2, Imerslund-Grasbeck syndrome, neurodegenerative disease and megaloblastic anemia.
How long is the AMN protein?
The Homo sapiens AMN protein (UniProt Q9BXJ7) is 453 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BXJ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BXJ7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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