Transmembrane protein 121B (TMEM121B)
Homo sapiens — UniProt Q9BXQ6
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 121B (TMEM121B) is a protein from Homo sapiens identified by UniProt accession Q9BXQ6, 578 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.
- UniProt accession: Q9BXQ6; gene symbol TMEM121B.
- Organism: Homo sapiens.
- Length: 578 amino acids.
- Top disease associations (Open Targets): interleukin 17 receptor A measurement, monocyte count and neutrophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 121B |
|---|---|
| UniProt accession | Q9BXQ6 |
| Gene | TMEM121B |
| Organism | Homo sapiens |
| Length | 578 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (38)
Diseases linked to this target (Open Targets).
- interleukin 17 receptor A measurement · score 0.43
- monocyte count · score 0.30
- neutrophil count · score 0.28
- leukocyte count · score 0.23
- monocyte percentage of leukocytes · score 0.23
- blood protein measurement · score 0.22
- myeloid white cell count · score 0.18
- eosinophil count · score 0.14
- eosinophil percentage of leukocytes · score 0.11
- lymphocyte percentage of leukocytes · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BXQ6-F1 | alphafold | PREDICTED | 59.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BXQ6.
Amino-acid sequence (578 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM121B?
The strongest Open Targets associations for TMEM121B are interleukin 17 receptor A measurement, monocyte count, neutrophil count, leukocyte count and monocyte percentage of leukocytes.
How long is the TMEM121B protein?
The Homo sapiens TMEM121B protein (UniProt Q9BXQ6) is 578 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BXQ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BXQ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.