Complement factor H-related protein 5 (CFHR5)
Homo sapiens — UniProt Q9BXR6
Data last refreshed: (UniProt release unknown)
Key facts
Complement factor H-related protein 5 (CFHR5) is a protein from Homo sapiens identified by UniProt accession Q9BXR6, 569 residues long. MolForge cross-references it against 0 known binders and 99 disease associations.
- UniProt accession: Q9BXR6; gene symbol CFHR5.
- Organism: Homo sapiens.
- Length: 569 amino acids.
- Top disease associations (Open Targets): C3 glomerulonephritis, chronic kidney disease and non-immunoglobulin-mediated membranoproliferative glomerulonephritis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Complement factor H-related protein 5 |
|---|---|
| UniProt accession | Q9BXR6 |
| Gene | CFHR5 |
| Organism | Homo sapiens |
| Length | 569 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (99)
Diseases linked to this target (Open Targets).
- C3 glomerulonephritis · score 0.67
- chronic kidney disease · score 0.57
- non-immunoglobulin-mediated membranoproliferative glomerulonephritis · score 0.51
- stage 5 chronic kidney disease · score 0.46
- Proteinuria · score 0.46
- blood protein measurement · score 0.45
- primary membranoproliferative glomerulonephritis · score 0.43
- kidney failure · score 0.37
- atypical hemolytic-uremic syndrome with anti-factor H antibodies · score 0.37
- coagulation factor measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BXR6-F1 | alphafold | PREDICTED | 83.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BXR6.
Amino-acid sequence (569 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CFHR5?
The strongest Open Targets associations for CFHR5 are C3 glomerulonephritis, chronic kidney disease, non-immunoglobulin-mediated membranoproliferative glomerulonephritis, stage 5 chronic kidney disease and Proteinuria.
How long is the CFHR5 protein?
The Homo sapiens CFHR5 protein (UniProt Q9BXR6) is 569 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BXR6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BXR6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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