Collagen alpha-1(XXV) chain (COL25A1)
Homo sapiens — UniProt Q9BXS0
Data last refreshed: (UniProt release unknown)
Key facts
Collagen alpha-1(XXV) chain (COL25A1) is a protein from Homo sapiens identified by UniProt accession Q9BXS0, 654 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.
- UniProt accession: Q9BXS0; gene symbol COL25A1.
- Organism: Homo sapiens.
- Length: 654 amino acids.
- Top disease associations (Open Targets): Congenital ptosis, sex hormone-binding globulin measurement and congenital fibrosis of the extraocular muscles.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Collagen alpha-1(XXV) chain |
|---|---|
| UniProt accession | Q9BXS0 |
| Gene | COL25A1 |
| Organism | Homo sapiens |
| Length | 654 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (90)
Diseases linked to this target (Open Targets).
- Congenital ptosis · score 0.68
- sex hormone-binding globulin measurement · score 0.37
- congenital fibrosis of the extraocular muscles · score 0.37
- congenital fibrosis of extraocular muscles · score 0.37
- Neurogenic arthrogryposis multiplex congenita · score 0.37
- breast adenocarcinoma · score 0.26
- genetic disorder · score 0.19
- lung adenocarcinoma · score 0.18
- endometrial cancer · score 0.14
- head and neck squamous cell carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BXS0-F1 | alphafold | PREDICTED | 57.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BXS0.
Amino-acid sequence (654 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COL25A1?
The strongest Open Targets associations for COL25A1 are Congenital ptosis, sex hormone-binding globulin measurement, congenital fibrosis of the extraocular muscles, congenital fibrosis of extraocular muscles and Neurogenic arthrogryposis multiplex congenita.
How long is the COL25A1 protein?
The Homo sapiens COL25A1 protein (UniProt Q9BXS0) is 654 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BXS0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BXS0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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