Transmembrane protein 59 (TMEM59)
Homo sapiens — UniProt Q9BXS4
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 59 (TMEM59) is a protein from Homo sapiens identified by UniProt accession Q9BXS4, 323 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q9BXS4; gene symbol TMEM59.
- Organism: Homo sapiens.
- Length: 323 amino acids.
- Top disease associations (Open Targets): Estrogen resistance syndrome, glioblastoma and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 59 |
|---|---|
| UniProt accession | Q9BXS4 |
| Gene | TMEM59 |
| Organism | Homo sapiens |
| Length | 323 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- Estrogen resistance syndrome · score 0.18
- glioblastoma · score 0.08
- neoplasm · score 0.03
- neuroblastoma · score 0.02
- anxiety · score 0.01
- cancer · score 0.01
- Autism · score 0.01
- Cognitive impairment · score 0.01
- infection · score 0.01
- Parkinson disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BXS4-F1 | alphafold | PREDICTED | 66.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BXS4.
Amino-acid sequence (323 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM59?
The strongest Open Targets associations for TMEM59 are Estrogen resistance syndrome, glioblastoma, neoplasm, neuroblastoma and anxiety.
How long is the TMEM59 protein?
The Homo sapiens TMEM59 protein (UniProt Q9BXS4) is 323 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BXS4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BXS4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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