Nucleolar and spindle-associated protein 1 (NUSAP1)
Homo sapiens — UniProt Q9BXS6
Data last refreshed: (UniProt release unknown)
Key facts
Nucleolar and spindle-associated protein 1 (NUSAP1) is a protein from Homo sapiens identified by UniProt accession Q9BXS6, 441 residues long. MolForge cross-references it against 0 known binders and 148 disease associations.
- UniProt accession: Q9BXS6; gene symbol NUSAP1.
- Organism: Homo sapiens.
- Length: 441 amino acids.
- Top disease associations (Open Targets): microcephaly, seizures, and developmental delay, developmental and epileptic encephalopathy and PHF-tau measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nucleolar and spindle-associated protein 1 |
|---|---|
| UniProt accession | Q9BXS6 |
| Gene | NUSAP1 |
| Organism | Homo sapiens |
| Length | 441 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (148)
Diseases linked to this target (Open Targets).
- microcephaly, seizures, and developmental delay · score 0.27
- developmental and epileptic encephalopathy · score 0.27
- PHF-tau measurement · score 0.19
- mean platelet volume · score 0.16
- asthma · score 0.16
- neutrophil percentage of leukocytes · score 0.15
- eosinophil count · score 0.15
- allergic rhinitis · score 0.15
- eosinophil percentage of leukocytes · score 0.14
- lymphocyte percentage of leukocytes · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BXS6-F1 | alphafold | PREDICTED | 61.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BXS6.
Amino-acid sequence (441 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NUSAP1?
The strongest Open Targets associations for NUSAP1 are microcephaly, seizures, and developmental delay, developmental and epileptic encephalopathy, PHF-tau measurement, mean platelet volume and asthma.
How long is the NUSAP1 protein?
The Homo sapiens NUSAP1 protein (UniProt Q9BXS6) is 441 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BXS6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BXS6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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