Fanconi anemia group D2 protein (FANCD2)
Homo sapiens — UniProt Q9BXW9
Data last refreshed: (UniProt release unknown)
Key facts
Fanconi anemia group D2 protein (FANCD2) is a protein from Homo sapiens identified by UniProt accession Q9BXW9, 1451 residues long. MolForge cross-references it against 0 known binders and 463 disease associations.
- UniProt accession: Q9BXW9; gene symbol FANCD2.
- Organism: Homo sapiens.
- Length: 1451 amino acids.
- Top disease associations (Open Targets): Fanconi anemia complementation group D2, Fanconi anemia and acute myeloid leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Fanconi anemia group D2 protein |
|---|---|
| UniProt accession | Q9BXW9 |
| Gene | FANCD2 |
| Organism | Homo sapiens |
| Length | 1451 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (463)
Diseases linked to this target (Open Targets).
- Fanconi anemia complementation group D2 · score 0.83
- Fanconi anemia · score 0.76
- acute myeloid leukemia · score 0.58
- genetic disorder · score 0.49
- myelodysplastic syndrome · score 0.46
- leukemia · score 0.46
- ovarian cancer · score 0.44
- neurodegenerative disease · score 0.40
- colorectal adenocarcinoma · score 0.40
- skin basal cell carcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BXW9-F1 | alphafold | PREDICTED | 76.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BXW9.
Amino-acid sequence (1451 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FANCD2?
The strongest Open Targets associations for FANCD2 are Fanconi anemia complementation group D2, Fanconi anemia, acute myeloid leukemia, genetic disorder and myelodysplastic syndrome.
How long is the FANCD2 protein?
The Homo sapiens FANCD2 protein (UniProt Q9BXW9) is 1451 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BXW9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BXW9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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