Transcription factor HES-7 (HES7)
Homo sapiens — UniProt Q9BYE0
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor HES-7 (HES7) is a protein from Homo sapiens identified by UniProt accession Q9BYE0, 225 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.
- UniProt accession: Q9BYE0; gene symbol HES7.
- Organism: Homo sapiens.
- Length: 225 amino acids.
- Top disease associations (Open Targets): autosomal recessive spondylocostal dysostosis, neurodegenerative disease and scoliosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor HES-7 |
|---|---|
| UniProt accession | Q9BYE0 |
| Gene | HES7 |
| Organism | Homo sapiens |
| Length | 225 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (123)
Diseases linked to this target (Open Targets).
- autosomal recessive spondylocostal dysostosis · score 0.67
- neurodegenerative disease · score 0.53
- scoliosis · score 0.34
- Tapered finger · score 0.34
- Brachycephaly · score 0.34
- Severe failure to thrive · score 0.34
- Intellectual disability · score 0.34
- Short neck · score 0.34
- Mitral regurgitation · score 0.34
- Hypophosphatemia · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BYE0-F1 | alphafold | PREDICTED | 73.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BYE0.
Amino-acid sequence (225 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HES7?
The strongest Open Targets associations for HES7 are autosomal recessive spondylocostal dysostosis, neurodegenerative disease, scoliosis, Tapered finger and Brachycephaly.
How long is the HES7 protein?
The Homo sapiens HES7 protein (UniProt Q9BYE0) is 225 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BYE0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BYE0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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