Gasdermin-C (GSDMC)
Homo sapiens — UniProt Q9BYG8
Data last refreshed: (UniProt release unknown)
Key facts
Gasdermin-C (GSDMC) is a protein from Homo sapiens identified by UniProt accession Q9BYG8, 508 residues long. MolForge cross-references it against 0 known binders and 177 disease associations.
- UniProt accession: Q9BYG8; gene symbol GSDMC.
- Organism: Homo sapiens.
- Length: 508 amino acids.
- Top disease associations (Open Targets): body height, monocyte count and body fat distribution.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gasdermin-C |
|---|---|
| UniProt accession | Q9BYG8 |
| Gene | GSDMC |
| Organism | Homo sapiens |
| Length | 508 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (177)
Diseases linked to this target (Open Targets).
- body height · score 0.48
- monocyte count · score 0.42
- body fat distribution · score 0.42
- neutrophil count · score 0.41
- eosinophil count · score 0.41
- leukocyte count · score 0.41
- heel bone mineral density · score 0.41
- lean body mass · score 0.40
- eosinophil percentage of leukocytes · score 0.40
- monocyte percentage of leukocytes · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BYG8-F1 | alphafold | PREDICTED | 74.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BYG8.
Amino-acid sequence (508 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GSDMC?
The strongest Open Targets associations for GSDMC are body height, monocyte count, body fat distribution, neutrophil count and eosinophil count.
How long is the GSDMC protein?
The Homo sapiens GSDMC protein (UniProt Q9BYG8) is 508 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BYG8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BYG8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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