About 3'-5' exoribonuclease HELZ2
3'-5' exoribonuclease HELZ2 (HELZ2) is a protein
from Homo sapiens identified by UniProt accession
Q9BYK8, 2896 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (84)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- Red cell distribution width · score 0.31
- lymphocyte count · score 0.25
- reticulocyte count · score 0.25
- reticulocyte measurement · score 0.24
- daytime rest measurement · score 0.23
- mean corpuscular volume · score 0.22
- basophil count · score 0.18
- serum gamma-glutamyl transferase measurement · score 0.18
- urate measurement · score 0.18
3D Structure (9)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q9BYK8.
Amino-acid sequence (2896 residues)
MAPPGSTLLP NSPAATRGPS LARLCALVDL CLGCSRCTQR LNESTYVLRR VEHDCSREIL LARFKQATKS KVWRVVGCRP TFPRPLCYQV CHYYSPGLGC RRHRNRCTFA RSREEALVWT FERQHNLQRL WLKAEVQGSG AQGGAGRAAD AILTEFGGRF ELLCSLCFRR CPPCICRVDP QGQCPEHGAC PSLLAHVSAE GRRKQQFVVV RPRPRAGQPP AYCRFVGRGQ PCWRGESRCQ FAHSAVEMAV WEAEQLGGLQ RGDLLTPPAP DGDGRTAPLG QPPGAQLYCP ACLVTCHSQE AFENHCASSE HAQMVAFDQA LPWEHRSPPP GLSKFELCPK PDLCEYGDAC TKAHSAQELQ EWVRRTQAVE LRGQAAWQDG LVPYQERLLA EYQRSSSEVL VLAETLDGVR VTCNQPLMYQ AQERKTQYSW TFAVHSEEPL LHVALLKQEP GADFSLVAPG LPPGRLYARG ERFRVPSSTA DFQVGVRVQA ASFGTFEQWV VFDFGRRPVL LQKLGLQLGQ GRRPGPCRNL ALGHPEEMER WHTGNRHVVP GVERTAEQTA LMAKYKGPAL ALEFNRSSVA SGPISPTNYR QRMHQFLYEE EAAQQQLVAK LTLRGQVFLK TALQTPALNM LFAPPGALYA EVPVPSSLMP DTDQGFLLGR AVSTALVAPV PAPDNTVFEV RLERRASSEQ ALWLLLPARC CLALGLQPEA RLVLEVQFQI DPMTFRLWHQ AVDTLPEEQL VVPDLPTCAL PRPWSVPPLR RGNRKQELAV ALIAGWGPGD GRRVPPLLIY GPFGTGKTYT LAMASLEVIR RPETKVLICT HTNSAADIYI REYFHSHVSG GHPEATPLRV MYTDRPLSQT DPVTLQYCCL TDDRQAFRPP TRAELARHRV VVTTTSQARE LRVPVGFFSH ILIDEAAQML ECEALTPLAY ASHGTRLVLA GDHMQVTPRL FSVARARAAE HTLLHRLFLC YQQETHEVAR QSRLVFHENY RCTDAIVSFI SRHFYVAKGN PIHARGKVPP HPRHYPLMFC HVAGSPDRDM SMASWLNLAE IAQVVEKVQE AYNTWPSCWG GREQRCICVV SHGAQVSALR QELRRRDLGQ VSVGSFEILP GRQFRVVVLS TVHTCQSLLS PGALAPEFFT DARVLNTVLT RAQSQLVVVG DAVALCSFGA CGKLWESFIR ECVERHSVCP EGLSMEQVEQ GVAQRRRWPP RGTQAGAAGN WEAAPEPVGD LAEEQAAVVT AMVKAEPGDE ALSPASRDIT ATTAQTEAAA APAGDAVKED VVPGACAAGA AAAAGVESTE AEDAEADFWP WDGELNADDA ILRELLDESQ KVMVTVGEDG LLDTVARPES LQQARLYENL PPAALRKLLH AEPERYRHCS FVPETFERAS AIPLDDASSG PIQVRGRLDC GMAFAGDEVL VQLLSGDKAP EGRLRGRVLG VLKRKRHELA FVCRMDTWDP RIMVPINGSV TKIFVAELKD PSQVPIYSLR KGRLQRVGLE RLTAEARHSR LFWVQIVLWR QGFYYPLGIV REVLPEASTW EQGLRILGLE YSLRVPPSDQ ATITKVLQKY HTELGRVAGR REDCRAFLTF TVDPQGACNL DDALSVRDLG PRCEVAVHIT DVASFVPRDG VLDVEARRQG AAFYAPGREP VPMLPASLCQ DVLSLLPGRD RLAISLFLTM EKASGQLKSL RFAPSVVQSD RQLSYEEAEE VIRQHPGAGR ELPARLDSVD ACVVAACYFS RLLRRHRLRS DCFYEQPDED GTLGFRAAHI MVKEYMIQFN RLVAEFLVGS ECTRTVTPLR WQPAPRSQQL KALCEKHGDR VPLSLHLGHH LHGGGGSPPD TRLHLLASLW KQVQFAARTQ DYEQMVDLVT TDDMHPFLAP AGRDLRKALE RSAFGRCARG HQQQGGHYSL QVDWYTWATS PIRRYLDVVL QRQILLALGH GGSAYSARDI DGLCQAFSLQ HALAQSYQRR ARSLHLAVQL KAQPLDKLGF VVDVEAGSRC FRLLFPSNRE TLPDPCPVPY GSLQLAEHPH ALAGRPGLRL LWRRRVYSAQ GSSPPLPLPG TVPDPHTLAV ETALWKQLLE LVELQRWPEA AALIQEKGEA SQRRELVQVQ RSHCGHFLEV ARELGSGDTL QVQLGTSLQH GFLVPSPQLW TVAPGFSLCL EHVERPGDCF SGRVYRAPRD RYRDVDEYAC VWEPFCALES ATGAVAENDS VTLQHLSVSW EASRTPQGQL QGAFRLEAAF LEENCADINF SCCYLCIRLE GLPAPTASPR PGPSSLGPGL NVDPGTYTWV AHGQTQDWDQ ERRADRQEAP RRVHLFVHHM GMEKVPEEVL RPGTLFTVEL LPKQLPDLRK EEAVRGLEEA SPLVTSIALG RPVPQPLCRV IPSRFLERQT YNIPGGRHKL NPSQNVAVRE ALEKPFTVIQ GPPGTGKTIV GLHIVFWFHK SNQEQVQPGG PPRGEKRLGG PCILYCGPSN KSVDVLAGLL LRRMELKPLR VYSEQAEASE FPVPRVGSRK LLRKSPREGR PNQSLRSITL HHRIRQAPNP YSSEIKAFDT RLQRGELFSR EDLVWYKKVL WEARKFELDR HEVILCTCSC AASASLKILD VRQILVDEAG MATEPETLIP LVQFPQAEKV VLLGDHKQLR PVVKNERLQN LGLDRSLFER YHEDAHMLDT QYRMHEGICA FPSVAFYKSK LKTWQGLRRP PSVLGHAGKE SCPVIFGHVQ GHERSLLVST DEGNENSKAN LEEVAEVVRI TKQLTLGRTV EPQDIAVLTP YNAQASEISK ALRREGIAGV AVSSITKSQG SEWRYVLVST VRTCAKSDLD QRPTKSWLKK FLGFVVDPNQ VNVAVTRAQE GLCLIGDHLL LRCCPLWRSL LDFCEAQQTL VPAGQVRVCR RPTMPS
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