Keratin-associated protein 4-6 (KRTAP4-6)
Homo sapiens — UniProt Q9BYQ5
Data last refreshed: (UniProt release unknown)
Key facts
Keratin-associated protein 4-6 (KRTAP4-6) is a protein from Homo sapiens identified by UniProt accession Q9BYQ5, 205 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q9BYQ5; gene symbol KRTAP4-6.
- Organism: Homo sapiens.
- Length: 205 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, head and neck squamous cell carcinoma and prostate adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin-associated protein 4-6 |
|---|---|
| UniProt accession | Q9BYQ5 |
| Gene | KRTAP4-6 |
| Organism | Homo sapiens |
| Length | 205 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- head and neck squamous cell carcinoma · score 0.18
- prostate adenocarcinoma · score 0.18
- breast adenocarcinoma · score 0.18
- thyroid gland adenocarcinoma · score 0.16
- esophageal cancer · score 0.14
- body mass index · score 0.07
- lean body mass · score 0.05
- body weight · score 0.04
- fat body mass · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BYQ5-F1 | alphafold | PREDICTED | 35.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BYQ5.
Amino-acid sequence (205 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRTAP4-6?
The strongest Open Targets associations for KRTAP4-6 are neurodegenerative disease, head and neck squamous cell carcinoma, prostate adenocarcinoma, breast adenocarcinoma and thyroid gland adenocarcinoma.
How long is the KRTAP4-6 protein?
The Homo sapiens KRTAP4-6 protein (UniProt Q9BYQ5) is 205 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BYQ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BYQ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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