Keratin-associated protein 4-11 (KRTAP4-11)
Homo sapiens — UniProt Q9BYQ6
Data last refreshed: (UniProt release unknown)
Key facts
Keratin-associated protein 4-11 (KRTAP4-11) is a protein from Homo sapiens identified by UniProt accession Q9BYQ6, 195 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q9BYQ6; gene symbol KRTAP4-11.
- Organism: Homo sapiens.
- Length: 195 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lean body mass and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin-associated protein 4-11 |
|---|---|
| UniProt accession | Q9BYQ6 |
| Gene | KRTAP4-11 |
| Organism | Homo sapiens |
| Length | 195 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- lean body mass · score 0.19
- glioblastoma multiforme · score 0.18
- prostate adenocarcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
- body mass index · score 0.18
- fat body mass · score 0.17
- thyroid gland adenocarcinoma · score 0.16
- whole body water mass · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BYQ6-F1 | alphafold | PREDICTED | 36.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BYQ6.
Amino-acid sequence (195 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRTAP4-11?
The strongest Open Targets associations for KRTAP4-11 are neurodegenerative disease, lean body mass, glioblastoma multiforme, prostate adenocarcinoma and head and neck squamous cell carcinoma.
How long is the KRTAP4-11 protein?
The Homo sapiens KRTAP4-11 protein (UniProt Q9BYQ6) is 195 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BYQ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BYQ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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