Pre-B-cell leukemia transcription factor 4 (PBX4)

About Pre-B-cell leukemia transcription factor 4

Pre-B-cell leukemia transcription factor 4 (PBX4) is a protein from Homo sapiens identified by UniProt accession Q9BYU1, 374 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.

Target properties

Protein name	Pre-B-cell leukemia transcription factor 4
UniProt accession	Q9BYU1
Gene	PBX4
Organism	Homo sapiens
Length	374 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (88)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.31
body height · score 0.25
lymphocyte count · score 0.23
eosinophil percentage of leukocytes · score 0.21
low density lipoprotein cholesterol measurement · score 0.20
total cholesterol measurement · score 0.19
neutrophil percentage of leukocytes · score 0.17
mathematical ability · score 0.16
sleep duration · score 0.16
basophil count · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BYU1-F1	alphafold	PREDICTED	72.42	—

Amino-acid sequence (374 residues)

MAAPPRPAPS PPAPRRLDTS DVLQQIMAIT DQSLDEAQAR KHALNCHRMK PALFSVLCEI KEKTVVSIRG IQDEDPPDAQ LLRLDNMLLA EGVCRPEKRG RGGAVARAGT ATPGGCPNDN SIEHSDYRAK LSQIRQIYHS ELEKYEQACR EFTTHVTNLL QEQSRMRPVS PKEIERMVGA IHGKFSAIQM QLKQSTCEAV MTLRSRLLDA RRKRRNFSKQ ATEVLNEYFY SHLNNPYPSE EAKEELARKG GLTISQVSNW FGNKRIRYKK NMGKFQEEAT IYTGKTAVDT TEVGVPGNHA SCLSTPSSGS SGPFPLPSAG DAFLTLRTLA SLQPPPGGGC LQSQAQGSWQ GATPQPATAS PAGDPGSINS STSN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards