Pre-B-cell leukemia transcription factor 4 (PBX4)
Homo sapiens — UniProt Q9BYU1
Data last refreshed: (UniProt release unknown)
Key facts
Pre-B-cell leukemia transcription factor 4 (PBX4) is a protein from Homo sapiens identified by UniProt accession Q9BYU1, 374 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.
- UniProt accession: Q9BYU1; gene symbol PBX4.
- Organism: Homo sapiens.
- Length: 374 amino acids.
- Top disease associations (Open Targets): eosinophil count, body height and lymphocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pre-B-cell leukemia transcription factor 4 |
|---|---|
| UniProt accession | Q9BYU1 |
| Gene | PBX4 |
| Organism | Homo sapiens |
| Length | 374 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (88)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.31
- body height · score 0.25
- lymphocyte count · score 0.23
- eosinophil percentage of leukocytes · score 0.21
- low density lipoprotein cholesterol measurement · score 0.20
- total cholesterol measurement · score 0.19
- neutrophil percentage of leukocytes · score 0.17
- mathematical ability · score 0.16
- sleep duration · score 0.16
- basophil count · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BYU1-F1 | alphafold | PREDICTED | 72.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BYU1.
Amino-acid sequence (374 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PBX4?
The strongest Open Targets associations for PBX4 are eosinophil count, body height, lymphocyte count, eosinophil percentage of leukocytes and low density lipoprotein cholesterol measurement.
How long is the PBX4 protein?
The Homo sapiens PBX4 protein (UniProt Q9BYU1) is 374 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BYU1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BYU1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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