Beta-defensin 126 (DEFB126)
Homo sapiens — UniProt Q9BYW3
Data last refreshed: (UniProt release unknown)
Key facts
Beta-defensin 126 (DEFB126) is a protein from Homo sapiens identified by UniProt accession Q9BYW3, 111 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q9BYW3; gene symbol DEFB126.
- Organism: Homo sapiens.
- Length: 111 amino acids.
- Top disease associations (Open Targets): lung adenocarcinoma, endometrial cancer and head and neck squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-defensin 126 |
|---|---|
| UniProt accession | Q9BYW3 |
| Gene | DEFB126 |
| Organism | Homo sapiens |
| Length | 111 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.24
- endometrial cancer · score 0.21
- head and neck squamous cell carcinoma · score 0.15
- Infertility · score 0.00
- varicocele · score 0.00
- cervical adenocarcinoma · score 0.00
- Azoospermia · score 0.00
- Reduced sperm motility · score 0.00
- infection · score 0.00
- infect · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BYW3-F1 | alphafold | PREDICTED | 72.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BYW3.
Amino-acid sequence (111 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEFB126?
The strongest Open Targets associations for DEFB126 are lung adenocarcinoma, endometrial cancer, head and neck squamous cell carcinoma, Infertility and varicocele.
How long is the DEFB126 protein?
The Homo sapiens DEFB126 protein (UniProt Q9BYW3) is 111 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BYW3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BYW3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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