2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (DPH1)
Homo sapiens — UniProt Q9BZG8
Data last refreshed: (UniProt release unknown)
Key facts
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (DPH1) is a protein from Homo sapiens identified by UniProt accession Q9BZG8, 438 residues long. MolForge cross-references it against 0 known binders and 171 disease associations.
- UniProt accession: Q9BZG8; gene symbol DPH1.
- Organism: Homo sapiens.
- Length: 438 amino acids.
- Top disease associations (Open Targets): developmental delay with short stature, dysmorphic facial features, and sparse hair 1, developmental delay with short stature, dysmorphic facial features, and sparse hair and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 |
|---|---|
| UniProt accession | Q9BZG8 |
| Gene | DPH1 |
| Organism | Homo sapiens |
| Length | 438 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (171)
Diseases linked to this target (Open Targets).
- developmental delay with short stature, dysmorphic facial features, and sparse hair 1 · score 0.75
- developmental delay with short stature, dysmorphic facial features, and sparse hair · score 0.64
- neurodegenerative disease · score 0.49
- congenital disorder of glycosylation · score 0.27
- PMM2-congenital disorder of glycosylation · score 0.27
- Global developmental delay · score 0.26
- Hydrocephalus · score 0.26
- Cerebellar vermis hypoplasia · score 0.26
- Dandy-Walker syndrome · score 0.26
- pancreatic adenocarcinoma · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BZG8-F1 | alphafold | PREDICTED | 86.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BZG8.
Amino-acid sequence (438 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DPH1?
The strongest Open Targets associations for DPH1 are developmental delay with short stature, dysmorphic facial features, and sparse hair 1, developmental delay with short stature, dysmorphic facial features, and sparse hair, neurodegenerative disease, congenital disorder of glycosylation and PMM2-congenital disorder of glycosylation.
How long is the DPH1 protein?
The Homo sapiens DPH1 protein (UniProt Q9BZG8) is 438 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BZG8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BZG8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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