Crooked neck-like protein 1 (CRNKL1)
Homo sapiens — UniProt Q9BZJ0
Data last refreshed: (UniProt release unknown)
Key facts
Crooked neck-like protein 1 (CRNKL1) is a protein from Homo sapiens identified by UniProt accession Q9BZJ0, 848 residues long. MolForge cross-references it against 0 known binders and 118 disease associations.
- UniProt accession: Q9BZJ0; gene symbol CRNKL1.
- Organism: Homo sapiens.
- Length: 848 amino acids.
- Top disease associations (Open Targets): cutaneous melanoma, skin squamous cell carcinoma and melanoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Crooked neck-like protein 1 |
|---|---|
| UniProt accession | Q9BZJ0 |
| Gene | CRNKL1 |
| Organism | Homo sapiens |
| Length | 848 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (118)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.31
- skin squamous cell carcinoma · score 0.30
- melanoma · score 0.22
- esophageal adenocarcinoma · score 0.19
- acute myeloid leukemia · score 0.19
- urinary bladder carcinoma · score 0.19
- hepatocellular carcinoma · score 0.19
- head and neck squamous cell carcinoma · score 0.19
- esophageal squamous cell carcinoma · score 0.19
- myelodysplastic syndrome · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BZJ0-F1 | alphafold | PREDICTED | 74.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BZJ0.
Amino-acid sequence (848 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CRNKL1?
The strongest Open Targets associations for CRNKL1 are cutaneous melanoma, skin squamous cell carcinoma, melanoma, esophageal adenocarcinoma and acute myeloid leukemia.
How long is the CRNKL1 protein?
The Homo sapiens CRNKL1 protein (UniProt Q9BZJ0) is 848 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BZJ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BZJ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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