Probable G-protein coupled receptor 63 (GPR63)
Homo sapiens — UniProt Q9BZJ6
Data last refreshed: (UniProt release unknown)
Key facts
Probable G-protein coupled receptor 63 (GPR63) is a protein from Homo sapiens identified by UniProt accession Q9BZJ6, 419 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q9BZJ6; gene symbol GPR63.
- Organism: Homo sapiens.
- Length: 419 amino acids.
- Top disease associations (Open Targets): isolated asymptomatic elevation of creatine phosphokinase, hypoparathyroidism, familial isolated, 2 and Primary hypomagnesemia with secondary hypocalcemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable G-protein coupled receptor 63 |
|---|---|
| UniProt accession | Q9BZJ6 |
| Gene | GPR63 |
| Organism | Homo sapiens |
| Length | 419 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- isolated asymptomatic elevation of creatine phosphokinase · score 0.06
- hypoparathyroidism, familial isolated, 2 · score 0.05
- Primary hypomagnesemia with secondary hypocalcemia · score 0.05
- pseudohypoparathyroidism type 2 · score 0.05
- Familial isolated hypoparathyroidism · score 0.04
- pentosuria · score 0.04
- body mass index · score 0.04
- 22q11.2 deletion syndrome · score 0.04
- Autosomal dominant primary hypomagnesemia with hypocalciuria · score 0.04
- hyperparathyroidism · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BZJ6-F1 | alphafold | PREDICTED | 74.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BZJ6.
Amino-acid sequence (419 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPR63?
The strongest Open Targets associations for GPR63 are isolated asymptomatic elevation of creatine phosphokinase, hypoparathyroidism, familial isolated, 2, Primary hypomagnesemia with secondary hypocalcemia, pseudohypoparathyroidism type 2 and Familial isolated hypoparathyroidism.
How long is the GPR63 protein?
The Homo sapiens GPR63 protein (UniProt Q9BZJ6) is 419 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BZJ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BZJ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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