F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1)
Homo sapiens — UniProt Q9BZK7
Data last refreshed: (UniProt release unknown)
Key facts
F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1) is a protein from Homo sapiens identified by UniProt accession Q9BZK7, 514 residues long. MolForge cross-references it against 0 known binders and 275 disease associations.
- UniProt accession: Q9BZK7; gene symbol TBL1XR1.
- Organism: Homo sapiens.
- Length: 514 amino acids.
- Top disease associations (Open Targets): Pierpont syndrome, intellectual disability, autosomal dominant 41 and diffuse large B-cell lymphoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box-like/WD repeat-containing protein TBL1XR1 |
|---|---|
| UniProt accession | Q9BZK7 |
| Gene | TBL1XR1 |
| Organism | Homo sapiens |
| Length | 514 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (275)
Diseases linked to this target (Open Targets).
- Pierpont syndrome · score 0.78
- intellectual disability, autosomal dominant 41 · score 0.73
- diffuse large B-cell lymphoma · score 0.59
- neurodegenerative disease · score 0.55
- asthma · score 0.45
- mean corpuscular volume · score 0.44
- Red cell distribution width · score 0.42
- hematocrit · score 0.40
- lymphoma · score 0.39
- Intellectual disability · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BZK7-F1 | alphafold | PREDICTED | 88.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BZK7.
Amino-acid sequence (514 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TBL1XR1?
The strongest Open Targets associations for TBL1XR1 are Pierpont syndrome, intellectual disability, autosomal dominant 41, diffuse large B-cell lymphoma, neurodegenerative disease and asthma.
How long is the TBL1XR1 protein?
The Homo sapiens TBL1XR1 protein (UniProt Q9BZK7) is 514 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BZK7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BZK7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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