Group XIIA secretory phospholipase A2 (PLA2G12A)

About Group XIIA secretory phospholipase A2

Group XIIA secretory phospholipase A2 (PLA2G12A) is a protein from Homo sapiens identified by UniProt accession Q9BZM1, 189 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	Group XIIA secretory phospholipase A2
UniProt accession	Q9BZM1
Gene	PLA2G12A
Organism	Homo sapiens
Length	189 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (49)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.62
triglyceride measurement · score 0.58
high density lipoprotein cholesterol measurement · score 0.58
lipoprotein measurement · score 0.51
mean corpuscular volume · score 0.47
HbA1c measurement · score 0.47
triglyceride:HDL cholesterol ratio · score 0.46
hematological measurement · score 0.34
testosterone measurement · score 0.33
neurodegenerative disease · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BZM1-F1	alphafold	PREDICTED	81.09	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BZM1.

Amino-acid sequence (189 residues)

MALLSRPALT LLLLLMAAVV RCQEQAQTTD WRATLKTIRN GVHKIDTYLN AALDLLGGED GLCQYKCSDG SKPFPRYGYK PSPPNGCGSP LFGVHLNIGI PSLTKCCNQH DRCYETCGKS KNDCDEEFQY CLSKICRDVQ KTLGLTQHVQ ACETTVELLF DSVIHLGCKP YLDSQRAACR CHYEEKTDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards