Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMNAT2)
Homo sapiens — UniProt Q9BZQ4
Data last refreshed: (UniProt release unknown)
Key facts
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMNAT2) is a protein from Homo sapiens identified by UniProt accession Q9BZQ4, 307 residues long. MolForge cross-references it against 0 known binders and 157 disease associations.
- UniProt accession: Q9BZQ4; gene symbol NMNAT2.
- Organism: Homo sapiens.
- Length: 307 amino acids.
- Top disease associations (Open Targets): reaction time measurement, systemic lupus erythematosus and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 |
|---|---|
| UniProt accession | Q9BZQ4 |
| Gene | NMNAT2 |
| Organism | Homo sapiens |
| Length | 307 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (157)
Diseases linked to this target (Open Targets).
- reaction time measurement · score 0.35
- systemic lupus erythematosus · score 0.33
- neurodegenerative disease · score 0.31
- genetic disorder · score 0.27
- cognitive function measurement · score 0.23
- vital capacity · score 0.23
- intelligence · score 0.22
- forced expiratory volume · score 0.21
- verbal-numerical reasoning measurement · score 0.20
- cystic lymphangioma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BZQ4-F1 | alphafold | PREDICTED | 79.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BZQ4.
Amino-acid sequence (307 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NMNAT2?
The strongest Open Targets associations for NMNAT2 are reaction time measurement, systemic lupus erythematosus, neurodegenerative disease, genetic disorder and cognitive function measurement.
How long is the NMNAT2 protein?
The Homo sapiens NMNAT2 protein (UniProt Q9BZQ4) is 307 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BZQ4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BZQ4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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