ER degradation-enhancing alpha-mannosidase-like protein 3 (EDEM3)
Homo sapiens — UniProt Q9BZQ6
Data last refreshed: (UniProt release unknown)
Key facts
ER degradation-enhancing alpha-mannosidase-like protein 3 (EDEM3) is a protein from Homo sapiens identified by UniProt accession Q9BZQ6, 932 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.
- UniProt accession: Q9BZQ6; gene symbol EDEM3.
- Organism: Homo sapiens.
- Length: 932 amino acids.
- Top disease associations (Open Targets): congenital disorder of glycosylation, type 2v, congenital disorder of glycosylation and complex neurodevelopmental disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ER degradation-enhancing alpha-mannosidase-like protein 3 |
|---|---|
| UniProt accession | Q9BZQ6 |
| Gene | EDEM3 |
| Organism | Homo sapiens |
| Length | 932 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (87)
Diseases linked to this target (Open Targets).
- congenital disorder of glycosylation, type 2v · score 0.73
- congenital disorder of glycosylation · score 0.37
- complex neurodevelopmental disorder · score 0.37
- sex hormone-binding globulin measurement · score 0.36
- body mass index · score 0.34
- body fat percentage · score 0.33
- body height · score 0.33
- Short stature · score 0.32
- self reported educational attainment · score 0.30
- refractive error measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BZQ6-F1 | alphafold | PREDICTED | 78.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BZQ6.
Amino-acid sequence (932 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EDEM3?
The strongest Open Targets associations for EDEM3 are congenital disorder of glycosylation, type 2v, congenital disorder of glycosylation, complex neurodevelopmental disorder, sex hormone-binding globulin measurement and body mass index.
How long is the EDEM3 protein?
The Homo sapiens EDEM3 protein (UniProt Q9BZQ6) is 932 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BZQ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BZQ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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