Interphotoreceptor matrix proteoglycan 2 (IMPG2)
Homo sapiens — UniProt Q9BZV3
Data last refreshed: (UniProt release unknown)
Key facts
Interphotoreceptor matrix proteoglycan 2 (IMPG2) is a protein from Homo sapiens identified by UniProt accession Q9BZV3, 1241 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.
- UniProt accession: Q9BZV3; gene symbol IMPG2.
- Organism: Homo sapiens.
- Length: 1241 amino acids.
- Top disease associations (Open Targets): retinitis pigmentosa, adult-onset foveomacular vitelliform dystrophy and Retinal dystrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interphotoreceptor matrix proteoglycan 2 |
|---|---|
| UniProt accession | Q9BZV3 |
| Gene | IMPG2 |
| Organism | Homo sapiens |
| Length | 1241 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (117)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.73
- adult-onset foveomacular vitelliform dystrophy · score 0.63
- Retinal dystrophy · score 0.56
- autosomal recessive retinitis pigmentosa · score 0.51
- vitelliform macular dystrophy 2 · score 0.47
- Posterior column ataxia - retinitis pigmentosa · score 0.42
- inherited retinal dystrophy · score 0.37
- Cone rod dystrophy · score 0.36
- total blood protein measurement · score 0.35
- mean corpuscular hemoglobin · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BZV3-F1 | alphafold | PREDICTED | 53.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BZV3.
Amino-acid sequence (1241 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IMPG2?
The strongest Open Targets associations for IMPG2 are retinitis pigmentosa, adult-onset foveomacular vitelliform dystrophy, Retinal dystrophy, autosomal recessive retinitis pigmentosa and vitelliform macular dystrophy 2.
How long is the IMPG2 protein?
The Homo sapiens IMPG2 protein (UniProt Q9BZV3) is 1241 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BZV3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BZV3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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