Transmembrane 6 superfamily member 1 (TM6SF1)
Homo sapiens — UniProt Q9BZW5
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane 6 superfamily member 1 (TM6SF1) is a protein from Homo sapiens identified by UniProt accession Q9BZW5, 370 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: Q9BZW5; gene symbol TM6SF1.
- Organism: Homo sapiens.
- Length: 370 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lymphocyte count and hair color.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane 6 superfamily member 1 |
|---|---|
| UniProt accession | Q9BZW5 |
| Gene | TM6SF1 |
| Organism | Homo sapiens |
| Length | 370 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- lymphocyte count · score 0.14
- hair color · score 0.09
- hair colour measurement · score 0.09
- bipolar disorder · score 0.09
- protein measurement · score 0.07
- age at menopause · score 0.07
- sex hormone-binding globulin measurement · score 0.06
- platelet crit · score 0.05
- smoking status measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BZW5-F1 | alphafold | PREDICTED | 92.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BZW5.
Amino-acid sequence (370 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TM6SF1?
The strongest Open Targets associations for TM6SF1 are neurodegenerative disease, lymphocyte count, hair color, hair colour measurement and bipolar disorder.
How long is the TM6SF1 protein?
The Homo sapiens TM6SF1 protein (UniProt Q9BZW5) is 370 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BZW5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BZW5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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