Natural killer cell receptor 2B4 (CD244)
Homo sapiens — UniProt Q9BZW8
Data last refreshed: (UniProt release unknown)
Key facts
Natural killer cell receptor 2B4 (CD244) is a protein from Homo sapiens identified by UniProt accession Q9BZW8, 370 residues long. MolForge cross-references it against 0 known binders and 157 disease associations.
- UniProt accession: Q9BZW8; gene symbol CD244.
- Organism: Homo sapiens.
- Length: 370 amino acids.
- Top disease associations (Open Targets): monocyte count, glioblastoma multiforme and rheumatoid arthritis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Natural killer cell receptor 2B4 |
|---|---|
| UniProt accession | Q9BZW8 |
| Gene | CD244 |
| Organism | Homo sapiens |
| Length | 370 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (157)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.22
- glioblastoma multiforme · score 0.19
- rheumatoid arthritis · score 0.18
- breast adenocarcinoma · score 0.18
- lymphocyte percentage of leukocytes · score 0.13
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- neoplasm · score 0.11
- low grade glioma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BZW8-F1 | alphafold | PREDICTED | 71.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BZW8.
Amino-acid sequence (370 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CD244?
The strongest Open Targets associations for CD244 are monocyte count, glioblastoma multiforme, rheumatoid arthritis, breast adenocarcinoma and lymphocyte percentage of leukocytes.
How long is the CD244 protein?
The Homo sapiens CD244 protein (UniProt Q9BZW8) is 370 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BZW8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BZW8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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