E3 ubiquitin-protein ligase TRIM31 (TRIM31)
Homo sapiens — UniProt Q9BZY9
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase TRIM31 (TRIM31) is a protein from Homo sapiens identified by UniProt accession Q9BZY9, 425 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.
- UniProt accession: Q9BZY9; gene symbol TRIM31.
- Organism: Homo sapiens.
- Length: 425 amino acids.
- Top disease associations (Open Targets): beta-2 microglobulin measurement, chronic obstructive pulmonary disease and MHC class I polypeptide-related sequence A measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRIM31 |
|---|---|
| UniProt accession | Q9BZY9 |
| Gene | TRIM31 |
| Organism | Homo sapiens |
| Length | 425 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (150)
Diseases linked to this target (Open Targets).
- beta-2 microglobulin measurement · score 0.26
- chronic obstructive pulmonary disease · score 0.25
- MHC class I polypeptide-related sequence A measurement · score 0.21
- lymphocyte count · score 0.17
- visual perception measurement · score 0.15
- mean platelet volume · score 0.14
- hepatocellular carcinoma · score 0.11
- type 1 diabetes mellitus · score 0.11
- autoimmune thyroid disease · score 0.11
- susceptibility to mumps measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9BZY9-F1 | alphafold | PREDICTED | 78.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9BZY9.
Amino-acid sequence (425 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRIM31?
The strongest Open Targets associations for TRIM31 are beta-2 microglobulin measurement, chronic obstructive pulmonary disease, MHC class I polypeptide-related sequence A measurement, lymphocyte count and visual perception measurement.
How long is the TRIM31 protein?
The Homo sapiens TRIM31 protein (UniProt Q9BZY9) is 425 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9BZY9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9BZY9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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