Homeobox protein Nkx-6.2 (NKX6-2)
Homo sapiens — UniProt Q9C056
Data last refreshed: (UniProt release unknown)
Key facts
Homeobox protein Nkx-6.2 (NKX6-2) is a protein from Homo sapiens identified by UniProt accession Q9C056, 277 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.
- UniProt accession: Q9C056; gene symbol NKX6-2.
- Organism: Homo sapiens.
- Length: 277 amino acids.
- Top disease associations (Open Targets): spastic ataxia 8, autosomal recessive, with hypomyelinating leukodystrophy, Autosomal recessive spastic ataxia with leukoencephalopathy and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homeobox protein Nkx-6.2 |
|---|---|
| UniProt accession | Q9C056 |
| Gene | NKX6-2 |
| Organism | Homo sapiens |
| Length | 277 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (138)
Diseases linked to this target (Open Targets).
- spastic ataxia 8, autosomal recessive, with hypomyelinating leukodystrophy · score 0.78
- Autosomal recessive spastic ataxia with leukoencephalopathy · score 0.46
- genetic disorder · score 0.19
- brain age measurement · score 0.14
- cortical surface area measurement · score 0.13
- visual perception measurement · score 0.13
- urate measurement · score 0.12
- bone density · score 0.12
- pulse pressure measurement · score 0.09
- systolic blood pressure · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9C056-F1 | alphafold | PREDICTED | 64.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9C056.
Amino-acid sequence (277 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NKX6-2?
The strongest Open Targets associations for NKX6-2 are spastic ataxia 8, autosomal recessive, with hypomyelinating leukodystrophy, Autosomal recessive spastic ataxia with leukoencephalopathy, genetic disorder, brain age measurement and cortical surface area measurement.
How long is the NKX6-2 protein?
The Homo sapiens NKX6-2 protein (UniProt Q9C056) is 277 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9C056 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9C056 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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