Histone-lysine N-methyltransferase SETD5 (SETD5)
Homo sapiens — UniProt Q9C0A6
Data last refreshed: (UniProt release unknown)
Key facts
Histone-lysine N-methyltransferase SETD5 (SETD5) is a protein from Homo sapiens identified by UniProt accession Q9C0A6, 1442 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.
- UniProt accession: Q9C0A6; gene symbol SETD5.
- Organism: Homo sapiens.
- Length: 1442 amino acids.
- Top disease associations (Open Targets): intellectual disability-facial dysmorphism syndrome due to SETD5 haploinsufficiency, Intellectual disability and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histone-lysine N-methyltransferase SETD5 |
|---|---|
| UniProt accession | Q9C0A6 |
| Gene | SETD5 |
| Organism | Homo sapiens |
| Length | 1442 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (123)
Diseases linked to this target (Open Targets).
- intellectual disability-facial dysmorphism syndrome due to SETD5 haploinsufficiency · score 0.81
- Intellectual disability · score 0.67
- genetic disorder · score 0.54
- neurodegenerative disease · score 0.45
- Neurodevelopmental disorder · score 0.44
- Global developmental delay · score 0.44
- body mass index · score 0.43
- KBG syndrome · score 0.42
- fat body mass · score 0.39
- type 2 diabetes mellitus · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9C0A6-F1 | alphafold | PREDICTED | 46.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9C0A6.
Amino-acid sequence (1442 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SETD5?
The strongest Open Targets associations for SETD5 are intellectual disability-facial dysmorphism syndrome due to SETD5 haploinsufficiency, Intellectual disability, genetic disorder, neurodegenerative disease and Neurodevelopmental disorder.
How long is the SETD5 protein?
The Homo sapiens SETD5 protein (UniProt Q9C0A6) is 1442 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9C0A6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9C0A6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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