(E3-independent) E2 ubiquitin-conjugating enzyme (UBE2O)
Homo sapiens — UniProt Q9C0C9
Data last refreshed: (UniProt release unknown)
Key facts
(E3-independent) E2 ubiquitin-conjugating enzyme (UBE2O) is a protein from Homo sapiens identified by UniProt accession Q9C0C9, 1292 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.
- UniProt accession: Q9C0C9; gene symbol UBE2O.
- Organism: Homo sapiens.
- Length: 1292 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, reticulocyte count and reticulocyte measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | (E3-independent) E2 ubiquitin-conjugating enzyme |
|---|---|
| UniProt accession | Q9C0C9 |
| Gene | UBE2O |
| Organism | Homo sapiens |
| Length | 1292 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (65)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- reticulocyte count · score 0.34
- reticulocyte measurement · score 0.33
- mean platelet volume · score 0.30
- mean corpuscular hemoglobin concentration · score 0.28
- lymphocyte percentage of leukocytes · score 0.26
- platelet component distribution width · score 0.26
- blood protein measurement · score 0.25
- lymphocyte count · score 0.25
- neutrophil percentage of leukocytes · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9C0C9-F1 | alphafold | PREDICTED | 65.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9C0C9.
Amino-acid sequence (1292 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UBE2O?
The strongest Open Targets associations for UBE2O are neurodegenerative disease, reticulocyte count, reticulocyte measurement, mean platelet volume and mean corpuscular hemoglobin concentration.
How long is the UBE2O protein?
The Homo sapiens UBE2O protein (UniProt Q9C0C9) is 1292 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9C0C9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9C0C9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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