Endoplasmic reticulum junction formation protein lunapark (LNPK)
Homo sapiens — UniProt Q9C0E8
Data last refreshed: (UniProt release unknown)
Key facts
Endoplasmic reticulum junction formation protein lunapark (LNPK) is a protein from Homo sapiens identified by UniProt accession Q9C0E8, 428 residues long. MolForge cross-references it against 0 known binders and 296 disease associations.
- UniProt accession: Q9C0E8; gene symbol LNPK.
- Organism: Homo sapiens.
- Length: 428 amino acids.
- Top disease associations (Open Targets): neurodevelopmental disorder with epilepsy and hypoplasia of the corpus callosum, wellbeing measurement and cystatin C measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Endoplasmic reticulum junction formation protein lunapark |
|---|---|
| UniProt accession | Q9C0E8 |
| Gene | LNPK |
| Organism | Homo sapiens |
| Length | 428 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (296)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with epilepsy and hypoplasia of the corpus callosum · score 0.65
- wellbeing measurement · score 0.30
- cystatin C measurement · score 0.30
- carpal tunnel syndrome · score 0.27
- peripheral nervous system disease · score 0.26
- neuroticism measurement · score 0.24
- depressive symptom measurement · score 0.24
- glomerular filtration rate · score 0.20
- Neurodevelopmental disorder · score 0.19
- Global developmental delay · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9C0E8-F1 | alphafold | PREDICTED | 67.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9C0E8.
Amino-acid sequence (428 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LNPK?
The strongest Open Targets associations for LNPK are neurodevelopmental disorder with epilepsy and hypoplasia of the corpus callosum, wellbeing measurement, cystatin C measurement, carpal tunnel syndrome and peripheral nervous system disease.
How long is the LNPK protein?
The Homo sapiens LNPK protein (UniProt Q9C0E8) is 428 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9C0E8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9C0E8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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