Rho GTPase-activating protein 39 (ARHGAP39)
Homo sapiens — UniProt Q9C0H5
Data last refreshed: (UniProt release unknown)
Key facts
Rho GTPase-activating protein 39 (ARHGAP39) is a protein from Homo sapiens identified by UniProt accession Q9C0H5, 1083 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q9C0H5; gene symbol ARHGAP39.
- Organism: Homo sapiens.
- Length: 1083 amino acids.
- Top disease associations (Open Targets): serum alanine aminotransferase measurement, optic cup area measurement and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho GTPase-activating protein 39 |
|---|---|
| UniProt accession | Q9C0H5 |
| Gene | ARHGAP39 |
| Organism | Homo sapiens |
| Length | 1083 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- serum alanine aminotransferase measurement · score 0.48
- optic cup area measurement · score 0.25
- type 2 diabetes mellitus · score 0.12
- Red cell distribution width · score 0.08
- hepatocellular carcinoma · score 0.08
- self reported educational attainment · score 0.06
- intelligence · score 0.06
- cognitive function measurement · score 0.06
- mean corpuscular hemoglobin concentration · score 0.05
- neoplasm · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9C0H5-F1 | alphafold | PREDICTED | 58.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9C0H5.
Amino-acid sequence (1083 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARHGAP39?
The strongest Open Targets associations for ARHGAP39 are serum alanine aminotransferase measurement, optic cup area measurement, type 2 diabetes mellitus, Red cell distribution width and hepatocellular carcinoma.
How long is the ARHGAP39 protein?
The Homo sapiens ARHGAP39 protein (UniProt Q9C0H5) is 1083 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9C0H5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9C0H5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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