Kelch-like protein 4 (KLHL4)
Homo sapiens — UniProt Q9C0H6
Data last refreshed: (UniProt release unknown)
Key facts
Kelch-like protein 4 (KLHL4) is a protein from Homo sapiens identified by UniProt accession Q9C0H6, 718 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q9C0H6; gene symbol KLHL4.
- Organism: Homo sapiens.
- Length: 718 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Down syndrome and Tetralogy of Fallot.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kelch-like protein 4 |
|---|---|
| UniProt accession | Q9C0H6 |
| Gene | KLHL4 |
| Organism | Homo sapiens |
| Length | 718 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- Down syndrome · score 0.02
- Tetralogy of Fallot · score 0.01
- adrenal cortex carcinoma · score 0.01
- endometrial carcinoma · score 0.01
- nervous system disease · score 0.01
- lung adenocarcinoma · score 0.01
- Intellectual disability · score 0.01
- obstructive sleep apnea · score 0.00
- cleft palate with or without ankyloglossia, X-linked · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9C0H6-F1 | alphafold | PREDICTED | 80.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9C0H6.
Amino-acid sequence (718 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLHL4?
The strongest Open Targets associations for KLHL4 are neurodegenerative disease, Down syndrome, Tetralogy of Fallot, adrenal cortex carcinoma and endometrial carcinoma.
How long is the KLHL4 protein?
The Homo sapiens KLHL4 protein (UniProt Q9C0H6) is 718 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9C0H6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9C0H6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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