Myotubularin-related protein 12 (MTMR12)
Homo sapiens — UniProt Q9C0I1
Data last refreshed: (UniProt release unknown)
Key facts
Myotubularin-related protein 12 (MTMR12) is a protein from Homo sapiens identified by UniProt accession Q9C0I1, 747 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q9C0I1; gene symbol MTMR12.
- Organism: Homo sapiens.
- Length: 747 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Alzheimer disease and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Myotubularin-related protein 12 |
|---|---|
| UniProt accession | Q9C0I1 |
| Gene | MTMR12 |
| Organism | Homo sapiens |
| Length | 747 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- Alzheimer disease · score 0.43
- lysosomal storage disease · score 0.43
- Parkinson disease · score 0.43
- multiple sclerosis · score 0.43
- neutrophil count · score 0.30
- monocyte count · score 0.24
- reticulocyte count · score 0.08
- neurofibrillary tangles measurement · score 0.05
- X-linked retinal dysplasia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9C0I1-F1 | alphafold | PREDICTED | 76.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9C0I1.
Amino-acid sequence (747 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MTMR12?
The strongest Open Targets associations for MTMR12 are neurodegenerative disease, Alzheimer disease, lysosomal storage disease, Parkinson disease and multiple sclerosis.
How long is the MTMR12 protein?
The Homo sapiens MTMR12 protein (UniProt Q9C0I1) is 747 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9C0I1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9C0I1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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