Thrombospondin type-1 domain-containing protein 7B (THSD7B)

Homo sapiens — UniProt Q9C0I4

Gene: THSD7BHomo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Thrombospondin type-1 domain-containing protein 7B (THSD7B) is a protein from Homo sapiens identified by UniProt accession Q9C0I4, 1606 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

UniProt accession: Q9C0I4; gene symbol THSD7B.
Organism: Homo sapiens.
Length: 1606 amino acids.
Top disease associations (Open Targets): mathematical ability, cognitive function measurement and attention deficit hyperactivity disorder.
3D structure: AlphaFold model available.

Target properties

Protein name	Thrombospondin type-1 domain-containing protein 7B
UniProt accession	Q9C0I4
Gene	THSD7B
Organism	Homo sapiens
Length	1606 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

mathematical ability · score 0.44
cognitive function measurement · score 0.42
attention deficit hyperactivity disorder · score 0.37
substance abuse · score 0.37
antisocial behaviour measurement · score 0.37
intelligence · score 0.36
age at menarche · score 0.36
smoking behavior · score 0.36
diet measurement · score 0.36
smoking initiation · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9C0I4-F1	alphafold	PREDICTED	67.06	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9C0I4.

Amino-acid sequence (1606 residues)

MFPKSNLTVT CWVWRSMRKL FLLLSLLLSH AAHLEGKKDN QFIWKPGPWG RCTGDCGPGG VQSRAVWCFH VDGWTSHLSN CGESNRPPKE RSCFRVCDWH SDLFQWEVSD WHHCVLVPYA RGEVKPRTAE CVTAQHGLQH RMVRCIQKLN RTVVANEICE HFALQPPTEQ ACLIPCPRDC VVSEFLPWSN CSKGCGKKLQ HRTRAVIAPP LFGGLQCPNL TESRACDAPI SCPLGEEEYT FSLKVGPWSK CRLPHLKEIN PSGRTVLDFN SDSNERVTFK HQSYKAHHHS KSWAIEIGYQ TRQVSCTRSD GQNAMLSLCL QDSFPLTVQS CIMPKDCETS QWSSWSPCSK TCRSGSLLPG FRSRSRNVKH MAIGGGKECP ELLEKEACIV EGELLQQCPR YSWRTSEWKE CQVSLLLEQQ DPHWHVTGPV CGGGIQTREV YCAQSVPAAA ALRAKEVSRP VEKALCVGPA PLPSQLCNIP CSTDCIVSSW SAWGLCIHEN CHDPQGKKGF RTRQRHVLME STGPAGHCPH LVESVPCEDP MCYRWLASEG ICFPDHGKCG LGHRILKAVC QNDRGEDVSG SLCPVPPPPE RKSCEIPCRM DCVLSEWTEW SSCSQSCSNK NSDGKQTRSR TILALAGEGG KPCPPSQALQ EHRLCNDHSC MQLHWETSPW GPCSEDTLVT ALNATIGWNG EATCGVGIQT RRVFCVKSHV GQVMTKRCPD STRPETVRPC FLPCKKDCIV TAFSEWTPCP RMCQAGNATV KQSRYRIIIQ EAANGGQECP DTLYEERECE DVSLCPVYRW KPQKWSPCIL VPESVWQGIT GSSEACGKGL QTRAVSCISD DNRSAEMMEC LKQTNGMPLL VQECTVPCRE DCTFTAWSKF TPCSTNCEAT KSRRRQLTGK SRKKEKCQDS DLYPLVETEL CPCDEFISQP YGNWSDCILP EGRREPHRGL RVQADSKECG EGLRFRAVAC SDKNGRPVDP SFCSSSGYIQ EKCVIPCPFD CKLSDWSSWG SCSSSCGIGV RIRSKWLKEK PYNGGRPCPK LDLKNQVHEA VPCYSECNQY SWVVEHWSSC KINNELRSLR CGGGTQSRKI RCVNTADGEG GAVDSNLCNQ DEIPPETQSC SLMCPNECVM SEWGLWSKCP QSCDPHTMQR RTRHLLRPSL NSRTCAEDSQ VQPCLLNENC FQFQYNLTEW STCQLSENAP CGQGVRTRLL SCVCSDGKPV SMDQCEQHNL EKPQRMSIPC LVECVVNCQL SGWTAWTECS QTCGHGGRMS RTRFIIMPTQ GEGRPCPTEL TQEKTCPVTP CYSWVLGNWS ACKLEGGDCG EGVQIRSLSC MVHSGSISHA AGRVEDALCG EMPFQDSILK QLCSVPCPGD CHLTEWSEWS TCELTCIDGR SFETVGRQSR SRTFIIQSFE NQDSCPQQVL ETRPCTGGKC YHYTWKASLW NNNERTVWCQ RSDGVNVTGG CSPQARPAAI RQCIPACRKP FSYCTQGGVC GCEKGYTEIM KSNGFLDYCM KVPGSEDKKA DVKNLSGKNR PVNSKIHDIF KGWSLQPLDP DGRVKIWVYG VSGGAFLIMI FLIFTSYLVC KKPKPHQSTP PQQKPLTLAY DGDLDM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with THSD7B?

The strongest Open Targets associations for THSD7B are mathematical ability, cognitive function measurement, attention deficit hyperactivity disorder, substance abuse and antisocial behaviour measurement.

How long is the THSD7B protein?

The Homo sapiens THSD7B protein (UniProt Q9C0I4) is 1606 amino acids long.

Browse: Targets: T · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q9C0I4 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q9C0I4 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.