Leucine-rich repeat-containing protein 27 (LRRC27)
Homo sapiens — UniProt Q9C0I9
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat-containing protein 27 (LRRC27) is a protein from Homo sapiens identified by UniProt accession Q9C0I9, 530 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q9C0I9; gene symbol LRRC27.
- Organism: Homo sapiens.
- Length: 530 amino acids.
- Top disease associations (Open Targets): age at first sexual intercourse measurement, coffee consumption measurement and attention deficit hyperactivity disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat-containing protein 27 |
|---|---|
| UniProt accession | Q9C0I9 |
| Gene | LRRC27 |
| Organism | Homo sapiens |
| Length | 530 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- age at first sexual intercourse measurement · score 0.30
- coffee consumption measurement · score 0.12
- attention deficit hyperactivity disorder · score 0.12
- antisocial behaviour measurement · score 0.12
- substance abuse · score 0.12
- risk-taking behaviour · score 0.11
- heel bone mineral density · score 0.10
- risky sexual behaviour measurement · score 0.09
- smoking status measurement · score 0.08
- neuroticism measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9C0I9-F1 | alphafold | PREDICTED | 62.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9C0I9.
Amino-acid sequence (530 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRC27?
The strongest Open Targets associations for LRRC27 are age at first sexual intercourse measurement, coffee consumption measurement, attention deficit hyperactivity disorder, antisocial behaviour measurement and substance abuse.
How long is the LRRC27 protein?
The Homo sapiens LRRC27 protein (UniProt Q9C0I9) is 530 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9C0I9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9C0I9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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