N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 (B3GNT4)
Homo sapiens — UniProt Q9C0J1
Data last refreshed: (UniProt release unknown)
Key facts
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 (B3GNT4) is a protein from Homo sapiens identified by UniProt accession Q9C0J1, 378 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q9C0J1; gene symbol B3GNT4.
- Organism: Homo sapiens.
- Length: 378 amino acids.
- Top disease associations (Open Targets): autosomal dominant nonsyndromic hearing loss, Hearing impairment and deafness.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 |
|---|---|
| UniProt accession | Q9C0J1 |
| Gene | B3GNT4 |
| Organism | Homo sapiens |
| Length | 378 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- autosomal dominant nonsyndromic hearing loss · score 0.12
- Hearing impairment · score 0.12
- deafness · score 0.12
- lean body mass · score 0.11
- body height · score 0.09
- fat body mass · score 0.08
- C-reactive protein measurement · score 0.08
- self reported educational attainment · score 0.04
- body mass index · score 0.03
- osteosarcoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9C0J1-F1 | alphafold | PREDICTED | 86.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9C0J1.
Amino-acid sequence (378 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with B3GNT4?
The strongest Open Targets associations for B3GNT4 are autosomal dominant nonsyndromic hearing loss, Hearing impairment, deafness, lean body mass and body height.
How long is the B3GNT4 protein?
The Homo sapiens B3GNT4 protein (UniProt Q9C0J1) is 378 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9C0J1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9C0J1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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