B-cell lymphoma/leukemia 11B (BCL11B)
Homo sapiens — UniProt Q9C0K0
Data last refreshed: (UniProt release unknown)
Key facts
B-cell lymphoma/leukemia 11B (BCL11B) is a protein from Homo sapiens identified by UniProt accession Q9C0K0, 894 residues long. MolForge cross-references it against 0 known binders and 599 disease associations.
- UniProt accession: Q9C0K0; gene symbol BCL11B.
- Organism: Homo sapiens.
- Length: 894 amino acids.
- Top disease associations (Open Targets): intellectual developmental disorder with speech delay, dysmorphic facies, and t-cell abnormalities, immunodeficiency 49 and schizophrenia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | B-cell lymphoma/leukemia 11B |
|---|---|
| UniProt accession | Q9C0K0 |
| Gene | BCL11B |
| Organism | Homo sapiens |
| Length | 894 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (599)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder with speech delay, dysmorphic facies, and t-cell abnormalities · score 0.73
- immunodeficiency 49 · score 0.68
- schizophrenia · score 0.52
- lean body mass · score 0.52
- genetic disorder · score 0.51
- body mass index · score 0.51
- bipolar disorder · score 0.49
- erythrocyte count · score 0.49
- hemoglobin measurement · score 0.49
- fat body mass · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9C0K0-F1 | alphafold | PREDICTED | 50.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9C0K0.
Amino-acid sequence (894 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BCL11B?
The strongest Open Targets associations for BCL11B are intellectual developmental disorder with speech delay, dysmorphic facies, and t-cell abnormalities, immunodeficiency 49, schizophrenia, lean body mass and genetic disorder.
How long is the BCL11B protein?
The Homo sapiens BCL11B protein (UniProt Q9C0K0) is 894 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9C0K0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9C0K0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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