Metal cation symporter ZIP8 (SLC39A8)
Homo sapiens — UniProt Q9C0K1
Data last refreshed: (UniProt release unknown)
Key facts
Metal cation symporter ZIP8 (SLC39A8) is a protein from Homo sapiens identified by UniProt accession Q9C0K1, 460 residues long. MolForge cross-references it against 0 known binders and 493 disease associations.
- UniProt accession: Q9C0K1; gene symbol SLC39A8.
- Organism: Homo sapiens.
- Length: 460 amino acids.
- Top disease associations (Open Targets): SLC39A8-CDG, congenital disorder of glycosylation type II and body mass index.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Metal cation symporter ZIP8 |
|---|---|
| UniProt accession | Q9C0K1 |
| Gene | SLC39A8 |
| Organism | Homo sapiens |
| Length | 460 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (493)
Diseases linked to this target (Open Targets).
- SLC39A8-CDG · score 0.78
- congenital disorder of glycosylation type II · score 0.68
- body mass index · score 0.55
- high density lipoprotein cholesterol measurement · score 0.55
- schizophrenia · score 0.54
- diastolic blood pressure · score 0.54
- systolic blood pressure · score 0.54
- neuroimaging measurement · score 0.54
- alcohol consumption measurement · score 0.54
- body fat percentage · score 0.53
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9C0K1-F1 | alphafold | PREDICTED | 73.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9C0K1.
Amino-acid sequence (460 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC39A8?
The strongest Open Targets associations for SLC39A8 are SLC39A8-CDG, congenital disorder of glycosylation type II, body mass index, high density lipoprotein cholesterol measurement and schizophrenia.
How long is the SLC39A8 protein?
The Homo sapiens SLC39A8 protein (UniProt Q9C0K1) is 460 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9C0K1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9C0K1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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