Ribosome biogenesis protein WDR12 (WDR12)
Homo sapiens — UniProt Q9GZL7
Data last refreshed: (UniProt release unknown)
Key facts
Ribosome biogenesis protein WDR12 (WDR12) is a protein from Homo sapiens identified by UniProt accession Q9GZL7, 423 residues long. MolForge cross-references it against 0 known binders and 99 disease associations.
- UniProt accession: Q9GZL7; gene symbol WDR12.
- Organism: Homo sapiens.
- Length: 423 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, coronary artery disease and hemoglobin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ribosome biogenesis protein WDR12 |
|---|---|
| UniProt accession | Q9GZL7 |
| Gene | WDR12 |
| Organism | Homo sapiens |
| Length | 423 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (99)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- coronary artery disease · score 0.22
- hemoglobin measurement · score 0.18
- coronary atherosclerosis · score 0.15
- myocardial infarction · score 0.14
- pulse pressure measurement · score 0.14
- stroke · score 0.13
- Myocardial Ischemia · score 0.13
- hematocrit · score 0.11
- white matter hyperintensity measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZL7-F1 | alphafold | PREDICTED | 89.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZL7.
Amino-acid sequence (423 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WDR12?
The strongest Open Targets associations for WDR12 are neurodegenerative disease, coronary artery disease, hemoglobin measurement, coronary atherosclerosis and myocardial infarction.
How long is the WDR12 protein?
The Homo sapiens WDR12 protein (UniProt Q9GZL7) is 423 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZL7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZL7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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