DNA-directed RNA polymerase II subunit RPB11-b1 (POLR2J2)
Homo sapiens — UniProt Q9GZM3
Data last refreshed: (UniProt release unknown)
Key facts
DNA-directed RNA polymerase II subunit RPB11-b1 (POLR2J2) is a protein from Homo sapiens identified by UniProt accession Q9GZM3, 115 residues long. MolForge cross-references it against 0 known binders and 5 disease associations.
- UniProt accession: Q9GZM3; gene symbol POLR2J2.
- Organism: Homo sapiens.
- Length: 115 amino acids.
- Top disease associations (Open Targets): chronotype measurement, type 2 diabetes mellitus and hemorrhoid.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA-directed RNA polymerase II subunit RPB11-b1 |
|---|---|
| UniProt accession | Q9GZM3 |
| Gene | POLR2J2 |
| Organism | Homo sapiens |
| Length | 115 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (5)
Diseases linked to this target (Open Targets).
- chronotype measurement · score 0.06
- type 2 diabetes mellitus · score 0.03
- hemorrhoid · score 0.03
- diverticulitis · score 0.03
- complication · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZM3-F1 | alphafold | PREDICTED | 93.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZM3.
Amino-acid sequence (115 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POLR2J2?
The strongest Open Targets associations for POLR2J2 are chronotype measurement, type 2 diabetes mellitus, hemorrhoid, diverticulitis and complication.
How long is the POLR2J2 protein?
The Homo sapiens POLR2J2 protein (UniProt Q9GZM3) is 115 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZM3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZM3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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