Nuclear distribution protein nudE-like 1 (NDEL1)
Homo sapiens — UniProt Q9GZM8
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear distribution protein nudE-like 1 (NDEL1) is a protein from Homo sapiens identified by UniProt accession Q9GZM8, 345 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q9GZM8; gene symbol NDEL1.
- Organism: Homo sapiens.
- Length: 345 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, genetic disorder and jaw-winking syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear distribution protein nudE-like 1 |
|---|---|
| UniProt accession | Q9GZM8 |
| Gene | NDEL1 |
| Organism | Homo sapiens |
| Length | 345 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.26
- genetic disorder · score 0.19
- jaw-winking syndrome · score 0.15
- Global developmental delay · score 0.12
- brain measurement · score 0.07
- aortic measurement · score 0.06
- cortical surface area measurement · score 0.06
- Lissencephaly · score 0.04
- epilepsy · score 0.04
- schizophrenia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZM8-F1 | alphafold | PREDICTED | 77.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZM8.
Amino-acid sequence (345 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NDEL1?
The strongest Open Targets associations for NDEL1 are neurodegenerative disease, genetic disorder, jaw-winking syndrome, Global developmental delay and brain measurement.
How long is the NDEL1 protein?
The Homo sapiens NDEL1 protein (UniProt Q9GZM8) is 345 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZM8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZM8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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