G protein-coupled receptor 88 (GPR88)
Homo sapiens — UniProt Q9GZN0
Data last refreshed: (UniProt release unknown)
Key facts
G protein-coupled receptor 88 (GPR88) is a protein from Homo sapiens identified by UniProt accession Q9GZN0, 384 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.
- UniProt accession: Q9GZN0; gene symbol GPR88.
- Organism: Homo sapiens.
- Length: 384 amino acids.
- Target class: GPCR.
- Top disease associations (Open Targets): chorea, childhood-onset, with psychomotor retardation, monocyte count and monocyte percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | G protein-coupled receptor 88 |
|---|---|
| UniProt accession | Q9GZN0 |
| Gene | GPR88 |
| Organism | Homo sapiens |
| Length | 384 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | GPCR (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (73)
Diseases linked to this target (Open Targets).
- chorea, childhood-onset, with psychomotor retardation · score 0.45
- monocyte count · score 0.33
- monocyte percentage of leukocytes · score 0.31
- leukocyte count · score 0.13
- lymphocyte count · score 0.12
- open-angle glaucoma · score 0.10
- eosinophil count · score 0.09
- glaucoma · score 0.09
- eosinophil percentage of leukocytes · score 0.07
- myeloid white cell count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZN0-F1 | alphafold | PREDICTED | 75.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZN0.
Amino-acid sequence (384 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPR88?
The strongest Open Targets associations for GPR88 are chorea, childhood-onset, with psychomotor retardation, monocyte count, monocyte percentage of leukocytes, leukocyte count and lymphocyte count.
How long is the GPR88 protein?
The Homo sapiens GPR88 protein (UniProt Q9GZN0) is 384 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZN0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZN0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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