Homeobox protein TGIF2 (TGIF2)
Homo sapiens — UniProt Q9GZN2
Data last refreshed: (UniProt release unknown)
Key facts
Homeobox protein TGIF2 (TGIF2) is a protein from Homo sapiens identified by UniProt accession Q9GZN2, 237 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.
- UniProt accession: Q9GZN2; gene symbol TGIF2.
- Organism: Homo sapiens.
- Length: 237 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, pancreatic adenocarcinoma and lung adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homeobox protein TGIF2 |
|---|---|
| UniProt accession | Q9GZN2 |
| Gene | TGIF2 |
| Organism | Homo sapiens |
| Length | 237 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (80)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- pancreatic adenocarcinoma · score 0.27
- lung adenocarcinoma · score 0.09
- lung cancer · score 0.07
- gut microbiome measurement · score 0.07
- Autism · score 0.06
- neoplasm · score 0.06
- hypoparathyroidism, familial isolated, 2 · score 0.06
- Primary hypomagnesemia with secondary hypocalcemia · score 0.06
- hepatocellular carcinoma · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9GZN2-F1 | alphafold | PREDICTED | 68.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9GZN2.
Amino-acid sequence (237 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TGIF2?
The strongest Open Targets associations for TGIF2 are neurodegenerative disease, pancreatic adenocarcinoma, lung adenocarcinoma, lung cancer and gut microbiome measurement.
How long is the TGIF2 protein?
The Homo sapiens TGIF2 protein (UniProt Q9GZN2) is 237 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9GZN2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9GZN2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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